Volume 8, Issue 1 (6-2026)
Tabari Biomed Stu Res J 2026, 8(1): 1-12 |
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Ethics code: IR.IAU.ET.REC.1402.030
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Ramezani Hombari F. The effect of common mutations in FABP2, FTO and MC4R genes of Tehranian obeses. Tabari Biomed Stu Res J 2026; 8 (1) :1-12
URL: http://tbsrj.mazums.ac.ir/article-1-3896-en.html
URL: http://tbsrj.mazums.ac.ir/article-1-3896-en.html
1. Genomics Research Laboratories, Health and Science Park, Shahid Beheshti University of Medical Sciences ,Tehran PC:(165964-4276), Iran,(ORCID ID:0009-0009-5841-8411).
Abstract:
Background: Obesity is a global epidemic caused by a combination of genetic and environmental factors. Polymorphisms in the FABP2, FTO and MC4R genes play a role in regulating metabolism and appetite. Common polymorphisms in these genes are associated with an increased risk of obesity and insulin resistance. These associations have been widely studied. The present study was designed to investigate the association between common polymorphisms of these genes and the risk of obesity in Teranian (Iranian) population.
Materials and methods:This case-control study involved selecting 100 obese individuals (BMI ≥30) and 100 normal-weight individuals (BMI 18.5–24.9). DNA samples were extracted from saliva, and the following polymorphisms were examined using PCR and Sanger sequencing:- FABP2 (rs1799883)- MC4R (rs17782313);- FTO (rs9939609).The data were analysed using statistical software such as SPSS and logistic regression tests.
Results:The rs9939609 polymorphism of the FTO gene was associated with a significant increase in the risk of obesity (OR: 1.9, 95% CI: 1.3–2.7, p < 0.001).The C allele of the MC4R gene (rs17782313) was associated with obese individuals (p < 0.001).- No significant association was observed between FABP2(rs 1799883)polymorphism and obesity in this population (p > 0.05).
Discussion and conclusion:These findings suggest that FTO and MC4R polymorphisms may be useful as genetic markers for predicting obesity risk in Teranian (Iranian) population. These results could suggest that the design of personalised strategies for obesity prevention and management is essential.Therefore, further studies that involve larger sample sizes and investigating gene-environment interactions are recommended.
Materials and methods:This case-control study involved selecting 100 obese individuals (BMI ≥30) and 100 normal-weight individuals (BMI 18.5–24.9). DNA samples were extracted from saliva, and the following polymorphisms were examined using PCR and Sanger sequencing:- FABP2 (rs1799883)- MC4R (rs17782313);- FTO (rs9939609).The data were analysed using statistical software such as SPSS and logistic regression tests.
Results:The rs9939609 polymorphism of the FTO gene was associated with a significant increase in the risk of obesity (OR: 1.9, 95% CI: 1.3–2.7, p < 0.001).The C allele of the MC4R gene (rs17782313) was associated with obese individuals (p < 0.001).- No significant association was observed between FABP2(rs 1799883)polymorphism and obesity in this population (p > 0.05).
Discussion and conclusion:These findings suggest that FTO and MC4R polymorphisms may be useful as genetic markers for predicting obesity risk in Teranian (Iranian) population. These results could suggest that the design of personalised strategies for obesity prevention and management is essential.Therefore, further studies that involve larger sample sizes and investigating gene-environment interactions are recommended.
Type of Study: Research (Original) |
Subject:
Genetics
Published: 2026/06/20 | ePublished: 2026/06/20
Published: 2026/06/20 | ePublished: 2026/06/20
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