en Midwifery Review <span style="font-size:11pt"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span new="" roman="" style="font-family:" times=""><span style="color:#002060"><span style="letter-spacing:.1pt">Introduction: </span></span></span></b><span new="" roman="" style="font-family:" times="">HPV is one of the most common sexually transmitted infections. The Gardasil vaccine can act as a prophylactic against the virus. Since parents are very important in adolescents &#39;decisions, this study is a review of interventions affecting parents&#39; knowledge and attitudes about HPV vaccine through a systematic review method.<span style="letter-spacing:.1pt"></span></span></span></span></span><br> <span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:11.0pt"><span style="color:#002060">Material and Methods:</span></span></b> <span style="font-size:11.0pt">This study was conducted in 2022 with steps, designing a study question, identifying related studies from 2005 to 2022. Selecting studies out of 818 studies, 10 articles were selected to announce the results and then the data were classified. The relevant search was performed in the available databases. The keywords were selected based on the mesh according to the text.</span><span style="font-size:11.0pt"></span></span></span><br> <span style="font-size:11pt"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span new="" roman="" style="font-family:" times=""><span style="color:#002060">Results:</span></span></b><span new="" roman="" style="font-family:" times=""> A total of 10 experimental and quasi-experimental studies were reviewed. The results of these studies were divided into four categories according to the type of intervention and the statistical population in the intervention group located in each study: face-to-face group education, virtual group education, community-based education, and intervention based on health belief model. Eight studies were conducted in the face-to-face and virtual group education category. In the community-based education category, the interventions were performed virtually and there is a study. The other category, which was related to the health belief model, also changed the knowledge and attitude of parents.</span></span></span></span><br> <b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#002060"><span style="letter-spacing:-.1pt">Conclusion:</span></span></span></span></b> <span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">The results showed that interventions for parents are effective in vaccination and changes in knowledge and attitude. Therefore, it is recommended that different methods of educational intervention be used to encourage parents to get the HPV vaccine for their adolescents.</span></span><span lang="EN" style="border:none; font-size:11.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""> </span></span></span> Attitude, HPV, Knowledge, Parents, Vaccine 36 47 http://tbsrj.mazums.ac.ir/browse.php?a_code=A-10-3553-1&slc_lang=en&sid=1 Zeinab Hamzehgardashi hamzehgardeshi@yahoo.com 100319475328460030790 100319475328460030790 Yes Sexual and Reproductive Health Research Center, Mazandaran University of Medical Sciences, Sari, Iran. Zohreh Keshavarz keshavarzzohre57@gmail.com 100319475328460030791 100319475328460030791 No Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Moloud Fakhri mmfir@yahoo.com 100319475328460030792 100319475328460030792 No Research Center for Traditional and Complementary Medicine, Addiction Treatment Research Institute, Mazandaran University of Medical Sciences, Sari, Iran. Maliheh Nasiri m.nasiri@sbmu.ac.ir 100319475328460030793 100319475328460030793 No School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Seyedeh Zeynab Hoseinnezhad zeynabhoseinnezhad@gamail.com 100319475328460030794 100319475328460030794 No School of Nursing and Midwifery, Mazandaran University of Medical Sciences, Sari, Iran. Leila Shasti midwife.roza.leila@gmail.com 100319475328460030795 100319475328460030795 No Student Research Committee, School of Nursing and Midwifery, Mazandaran University of Medical Sciences, Sari, Iran.