Tabari Biomedical Student Research Journal

en Investigating the Relationship between Vitamin D Status and Multiple Sclerosis; A Case-Control Study Neurology Research (Original) Introduction: Multiple Sclerosis (MS) affects the central nervous system, causing significant impairments in movement and sensory functions. Genetic and environmental factors, including vitamin D deficiency, play crucial roles in MS susceptibility and severity. Methods: Ninety-six MS patients were examined, and divided into patient (n=48) and control (n=48) groups matched for age and gender. Various parameters like age, disease onset, vitamin D levels, hair color, sunlight exposure, and sunscreen use were analyzed. Disease severity was assessed using the Expanded Disability Status Scale (EDSS) scores. Results: Statistical analysis revealed significant differences in age, disease onset, serum vitamin D levels, hair color, and sunscreen use at 40 years old between patient and control groups. However, no significant variances were found in gender, age, eye color, and vitamin D levels based on disease type or EDSS scores. Notably, no substantial correlation was established between vitamin D levels and disability severity in MS patients, potentially due to suboptimal vitamin D supplementation. Conclusion: Patients with MS exhibited significantly lower levels of vitamin D compared to the control group. No significant correlation was found between vitamin D levels and the severity of disability in MS patients. This lack of correlation could be attributed to the suboptimal administration of vitamin D in MS patients.   multiple sclerosis, vitamin D, case-control 16 26 http://tbsrj.mazums.ac.ir/browse.php?a_code=A-10-3575-3&slc_lang=en&sid=1 Mohammadreza Khanpour khanpour@gmail.com 100319475328460031792 100319475328460031792 No Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Mehran Frouzanian Frouzanian@gmail.com 100319475328460031793 100319475328460031793 Yes Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Seyed Mohammad Baghbanian mohammadbaghbanian@gmail.com 100319475328460031794 100319475328460031794 No Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Hatef Ghasemi Hamidabadi hatef@gmail.com 100319475328460031795 100319475328460031795 No Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Abbas Khonakdar Khonakdar@gmail.vom 100319475328460031796 100319475328460031796 No Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Hamed Cheraghmakani cheraghmakani@gmail.com 100319475328460031797 100319475328460031797 No Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Amirsaleh Abdollahi 100319475328460031798 100319475328460031798 No Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran