Tabari Biomedical Student Research Journal

en Evaluation of the diagnostic value of procalcitonin in acute pyelonephritis indices in patients referred to the hospital Virology Research (Original) Abstract Introduction: Uncomplicated urinary tract infection (UTI) is a widespread global ailment. The aim of this investigation was to evaluate the diagnostic efficacy of procalcitonin (PCT) in discriminating acute pyelonephritis from other lower urinary tract infections. Methods: This applied research concentrated on patients with acute pyelonephritis who were referred to Hazrat Valiasr Qaemshahr Hospital. A straightforward (random) sampling technique was implemented. Leukocyte count, ESR, serum CRP, and PCT measurements were obtained from all patients. Results: Procalcitonin demonstrated positive results in 98.5% of pyelonephritis cases and 5% of cystitis cases, signifying a statistically significant differentiation (P=0.001). The diagnostic accuracy of procalcitonin was 97.7%, while its sensitivity and specificity were 98.5% and 95%, respectively. A notable correlation between serum PCT and CRP levels was observed in patients with acute pyelonephritis (P=0.038). The serum level of PCT in patients with acute pyelonephritis did not manifest any statistically significant variances based on age, gender, or history of urinary tract infection (P > 0.05). Discussion and Conclusion: Based on the findings of this study and comparisons with existing research, it can be deduced that procalcitonin functions as a dependable indicator for distinguishing acute pyelonephritis from other urinary tract infections. Consequently, its utilization for this purpose is recommended. Ultimately, conducting further studies with a larger sample size and in a multicenter manner is advised to validate the findings obtained in this study. Keywords: Acute pyelonephritis, leukocyte count, erythrocyte sedimentation rate, C-reactive protein, procalcitonin. 55 61 http://tbsrj.mazums.ac.ir/browse.php?a_code=A-10-3581-2&slc_lang=en&sid=1 Reza Yekani Rezaayekani@gmail.com 100319475328460031416 100319475328460031416 No Department of Biochemistry and Biophysics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran,Iran. Melody Omraninava omraninavamelody@gmail.com 100319475328460031417 100319475328460031417 Yes Assistant Professor, Hospital Administration Research Center ,Sari Branch, Islamic Azad University, Sari, Iran. Farzam Nasrollahnejad rezayekani1822@gmail.com 100319475328460031418 100319475328460031418 No Department of Medical Sciences, Faculty of Medicine, Sari Branch, Islamic Azad University, Sari, Iran. Fatemeh Ghasemi Talouki baratiali272@gmail.com 100319475328460031419 100319475328460031419 No Department of Medical Sciences, Faculty of Medicine, Sari Branch, Islamic Azad University, Sari, Iran. Shahriyar Namdar rezayekani8@gmail.com 100319475328460031420 100319475328460031420 No Assitant Professor, Neurology Department, Faculty of Medicine, Sari Branch, Islamic Azad University, Sari,Iran.