en Microbiology Research (Original) <span style="font-size:12pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="color:#002060">Introduction: </span></span></b><em><span style="font-size:11.0pt">Staphylococcus aureus</span></em><span style="font-size:11.0pt"> is recognized as a significant pathogenic agent in human diseases. Nasal carriage of Staphylococcus aureus is an independent risk factor for hospital-acquired infections, particularly surgical site infections. This study aimed to investigate the frequency and antibiotic resistance pattern of S. aureus strain isolates from the nasal carriage of operating room personnel in a referral hospital in Qaemshahr.</span></span></span></span><br> <span style="font-size:12pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="color:#002060">Material and Methods:</span></span></b><span style="font-size:11.0pt"> This study was conducted on 65 personnel in the surgical and operating room departments (morning, evening, and night shifts) in 2022. The sampling method was census-based, and a checklist containing demographic information, underlying diseases, work history, history of antibiotic use, etc., was employed.</span><span style="font-size:9.0pt"></span></span></span></span><br> <span style="font-size:12pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="color:#002060">Results:</span></span></b><span style="font-size:11.0pt"> The result of nasal swab culture in 10 individuals (15.4%) was positive. Also, the results showed a higher carrier frequency in the age group over 40 years (21.7%), among males (22.6%), in the nursing profession (15.56%), in personnel with more than 10 years of experience in the surgical department (24%), and with a work history in the hospital exceeding 13 years (25%). Furthermore, the results indicated higher sensitivity to rifampin and cefazolin in this descriptive study. Regarding clindamycin and oxacillin, relative sensitivity was observed.</span><span style="font-size:9.0pt"></span></span></span></span><br> <span style="font-size:12pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="color:#002060">Conclusion:</span></span></b><span style="font-size:11.0pt"> In general, the results indicated that antibiotic resistance to ciprofloxacin, trimethoprim-sulfamethoxazole, erythromycin, clindamycin, and oxacillin was higher in Staphylococcus aureus infections. Therefore, it is suggested to investigate the causes of antibiotic resistance to these drugs to prevent further resistance compared to other antibiotics.</span></span></span></span><br> &nbsp; Nasal Carriers, Antibiotic Resistance, Staphylococcus Aureus 29 37 http://tbsrj.mazums.ac.ir/browse.php?a_code=A-10-3580-7&slc_lang=en&sid=1 Melody Omraninava 100319475328460031396 100319475328460031396 Yes Hospital Administration Research Center, Sari Branch, Islamic Azad University, Sari, Iran Iraj Mohammdi 100319475328460031397 100319475328460031397 No Department of Basic Sciences, Faculty of Medicine, Sari Branch, Islamic Azad University, Sari, Iran Mina Owrang 100319475328460031398 100319475328460031398 No Microbiology Department, Faculty of Medicine, Sari Branch, Islamic Azad University, Sari, Iran Hashem Hashempour 100319475328460031399 100319475328460031399 No Anesthesiology Department, Faculty of Medicine, Sari Branch, Islamic Azad University, Sari, Iran Taha Ashouri 100319475328460031400 100319475328460031400 No Department of Medical Sciences, Faculty of Medicine, Sari Branch, Islamic Azad University, Sari, Iran Mohammad Mahdi Rabiei Ghadi 100319475328460031401 100319475328460031401 No Department of Medical Sciences, Faculty of Medicine, Sari Branch, Islamic Azad University, Sari, Iran Reza Najafi 100319475328460031402 100319475328460031402 No Valieasr Hospital, Specific Clinic Medical Laboratory, Qaemshahr, Iran