en Health Review Cancer incidence and mortality rates in developing countries, including Iran, reveal significant disparities compared to developed nations, with skin cancers representing a growing public health concern. This review explores the multifaceted challenges contributing to these disparities, emphasizing healthcare infrastructure, access to dermatologic diagnosis and treatment, and socioeconomic determinants. Limitations in specialized dermatology services and advanced diagnostic tools restrict timely identification and management of skin cancers. Geographic and economic barriers further impede access to cancer care facilities, while financial burdens and referral delays exacerbate these challenges. Additionally, low public awareness regarding skin cancer prevention, early detection, and the importance of dermatologic evaluation contributes to late-stage presentations. This article underscores the need for national policies, standardized diagnostic protocols, and expanded access to screening programs for skin cancer. Emphasizing data-driven strategies, equitable resource allocation, and targeted interventions, this review highlights the critical role of dermatology in improving skin cancer care and outcomes in Iran. Neoplasms, Cancer care facilities, Developing countries, Delivery of health care, Healthcare disparities, Socioeconomic factors, Socioeconomic disparities in health, Resource allocation, Health resources 10 23 http://tbsrj.mazums.ac.ir/browse.php?a_code=A-10-3575-6&slc_lang=en&sid=1 Mehran Frouzanian frouzanian@gmail.com 100319475328460032030 100319475328460032030 No Amirsaleh Abdollahi amirsalehabdellahi@gmail.com 100319475328460032031 100319475328460032031 Yes