en Biochemistry Research (Original) <span style="font-size:12pt"><span style="line-height:90%"><span new="" roman="" style="font-family:" times=""><b><span style="color:#1f3864">Introduction: </span></b>COVID-19 has been associated with multiple organ injuries, contributing to increased morbidity and mortality in hospitalized patients. This study aimed to investigate the prevalence of cardiac, renal, and hepatic injuries among deceased and ICU-admitted COVID-19 patients at Imam Sari Hospital.</span></span></span><br> <span style="font-size:12pt"><span style="line-height:90%"><span new="" roman="" style="font-family:" times=""><b><span style="color:#1f3864">Methods:</span></b> A total of 600 patients were included in this cross-sectional study. Demographic data and clinical histories were collected. The presence of organ injuries was determined by a medical team based on laboratory findings and CT scans. Statistical analyses were performed using SPSS version 26, with a significance level set at 0.05. Descriptive statistics and appropriate inferential tests (independent sample t-test, Pearson Chi-square) were used to analyze the data.</span></span></span><br> <span style="font-size:12pt"><span style="line-height:90%"><span new="" roman="" style="font-family:" times=""><b><span style="color:#002060">Results:</span></b> The mean age of patients was 51.83 &plusmn; 16.70 years, with most patients (42.3%) aged 61&ndash;75. Males comprised 53% of the sample. The prevalence of cardiac, renal, and hepatic injuries was 32.0%, 13.7%, and 3.7%, respectively. Older age was significantly associated with all three types of injuries (P < 0.05). No significant association was found between gender and organ injury prevalence. Mortality rates were significantly higher among patients with cardiac (45.8% vs. 5.4%), renal (57.3% vs. 12.2%), and hepatic (36.4% vs. 17.6%) injuries compared to those without these injuries (P < 0.05 for all).</span></span></span><br> <b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#002060">Conclusion:</span></span></span></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Cardiac, renal, and hepatic injuries are prevalent among severe COVID-19 cases, especially in older patients, and are strongly linked to increased mortality. Gender does not appear to influence the risk of these injuries. </span></span> COVID-19 ,Cardiac Injury ,Renal Injury ,Hepatic Injury , Prevalence ,Mortality ,Multiple Organ Dysfunction 31 44 http://tbsrj.mazums.ac.ir/browse.php?a_code=A-10-1703-1&slc_lang=en&sid=1 Fereshteh Ahmadipour msc.musavi66@gmail.com 100319475328460031962 100319475328460031962 No Department of Biochemistry and Molecular Biology, Shahid University of Medical Sciences, Sari, Iran. fatemeh Lotfi Asrami 100319475328460031963 100319475328460031963 No Department of Biochemistry, Biophysics, Genetics and Nutrition, School of Medicine Metabolic Disorders Research Center, Golestan University of Medical Sciences abbas Khonakdar-Tarsi khonakdarab@gmail.com 100319475328460031964 100319475328460031964 No Department of Medical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.. narjes Mohammadzadeh shaghayegh.msc75@gmail.com 100319475328460031965 100319475328460031965 Yes Department of Medical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran..