en Health Review <span style="font-size:11pt"><span style="line-height:200%"><span style="font-family:Calibri,sans-serif"><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">The unique characteristics of today&#39;s humans, such as their brains, are the result of millions of years of evolution in a very healthy environment. Thousands and millions of years ago, the environment was not manipulated like it is now, and the climate was not polluted by human activities like it is today. At that time, people ate organic food and enjoyed a healthy climate. Today, humans live in an industrialized world, and eating processed foods has become a part of their daily habits. Drinks and foods that have different additive compounds, alcoholic beverages, drugs/smoking, and all kinds of fast foods have changed the human diet. </span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">The consumption</span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""> of fruits and vegetables grown in </span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">environments</span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""> contaminated with heavy metals and various poisons and fertilizers is a </span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">major</span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""> challenge in food health. Human sleep and wake cycles today are very different from </span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">those of </span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">thousands of years ago </span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">because of</span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""> the presence of night lighting facilities, night jobs, and entertainment. Therefore, the lifestyle of today&#39;s man can affect his organs, sex cells, and embryonic period, and finally, he can face a serious challenge to the development of his nervous system. </span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">This</span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""> type of lifestyle </span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">is associated </span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">with oxidative stress, inflammation of the brain, and various diseases of the central nervous system</span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">,</span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""> such as anxiety, depression, and memory impairments. As a result, today&#39;s man</span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">,</span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""> with his manipulations in the world in which he lives</span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">,</span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""> causes his advanced nervous system, which results from millions of years of evolution, to face </span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">challenges</span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">.</span></span></span></span></span></span><br> &nbsp; nervous system, environment, development, lifestyle, pollution 21 33 http://tbsrj.mazums.ac.ir/browse.php?a_code=A-10-3606-1&slc_lang=en&sid=1 Mohammad Saleh Ranaiy ms.ranaiy@gmail.com 100319475328460032116 100319475328460032116 No Student Research Committee, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran Dina Rajabizadeh dina.rajabizadeh@gmail.com 100319475328460032117 100319475328460032117 No Student Research Committee, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran Hamed Ghazvini hghazvini1@gmail.com 100319475328460032118 100319475328460032118 No Department of Neuroscience, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran Seyedeh Masoumeh Seyedhoseini Tamijani Seyedhoseini_sm@yahoo.com 100319475328460032119 100319475328460032119 No Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran. Hamid Kalalian-Moghaddam h.kalalian@shmu.ac.ir 100319475328460032120 100319475328460032120 No Center for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran. Fahimeh Mohseni fahime.mohseni123@gmail.com 100319475328460032121 100319475328460032121 No Department of Addiction Studies, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran. Raheleh Rafaiee rachel.rafaie@yahoo.com 100319475328460032122 100319475328460032122 Yes Department of Neuroscience, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.