Tabari Biomedical Student Research Journal

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Backgrounds & Purpose: Nowadays the narcotics are one of the major problems facing human societies. It has global expansion. Based on clinical observation, in most cases, certain mental, emotional and behavioral disorders are related to addiction. Because of this thread we decided to check the prevalence of addiction to drugs in patients admitted to the psychiatric sector of Zare hospital in sari city during March 20, 2012 to March 20, 2013. Materials & Methods: This is a retrospective research and data were collected from medical files in Zare hospital. The data were collected using a two section questionnaires the first part consisted of demographic questions, and the second section was based on the results of tests. Data were analyzed with descriptive statistics, Chi 2 test by using SPSS V.18.0. (P<0.05) were considered statistically significant. Results: 1380 patients including 1030 Male (75%) and 350 Female (25%) with 35 years age average. Analysis showed Methamphetamine was positive in 73 cases (5.9%), Methadone 159 (11.2%), Morphine 242 (18.7%) that was the most frequent, Marijuana was positive in 40 (3.1%) cases and then Cocaine test was negative in all cases. In Morphine test the most positive cases were among 40 to 50 years old, however in other tests were 20 to 40 years. Between Gender and results of tests data were statistically significant (P<0.05). There were no significant relations between results and age (P>0.05) but in Morphine was significant (P=0.048). Conclusion: Since in Iran young people significantly are vulnerable to addiction and their disorders, also higher prevalence of mental disorders in addicts compared to general and health peoples, this case should be considered.

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mTOR/S6K1 signaling pathway is a center of cell growth and survival and dysregulation of this pathway is involved in the incidence of many cancers. MiRNAs are key regulators of gene expression at post-translational levels and their dysregulation is considered in many cancers. There are various methods for detection of miRNAs. Regarding extensive development of bioinformatics, these applications can be utilized for prediction of miRNAs and their target genes with acceptable accuracy. Therefore, the aim of this study was to apply bioinformatic software and programs, as a low cost method for prediction of miRNAs targeting mTOR/S6K1 signaling pathway. Prediction of miRNAs targeting mTOR and S6K1 genes was performed using bioinformatic software and programs named TargetScan, miRBase, miRanda, microCosm, microPIR, miRDB, miRSearch, miRWalk, DIANA-microT, PicTar, TarBase, miRTarBase, miRNAMap and MirZ bioinformatics tools Hsa-miR-100-5p, hsa-miR-99a-5p, hsa-miR-199a-3p, hsa-miR-99b-5p and hsa-miR-96-5p had the highest score and repeat among all databases to target 3ʹ-UTR of mTOR and hsa-miR-557, hsa-miR-362-5p, hsa-miR-500a-5p, hsa-miR-223-3p and hsa-miR-200c-3p had the highest score to target 3ʹ-UTR of S6K1. Bioinformatic approaches are accessible and low-cost techniques to find miRNAs targeting genes in different signaling pathways. Considering the role of mTOR/S6K1 signaling pathway in cell growth and survival and its dysregulation in different cancers, miRNAs that suppress this signaling pathway can be utilized as a potential effective therapeutic and diagnostic tool.
 

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Introduction: The ever-increasing advancements on the World Wide Web and the countless increase in its users, especially among the university students, caused many problems. The internet addiction in the students is one of the significant problems which can have adverse effect on their health as well as their academic performance. Therefore, we intended to study the internet addiction among the students of Semnan University of Medical Sciences.
Material and Methods: Two hundred sixty students of the Semnan University of Medical Sciences were randomly sampled and entered into this descriptive-analytical study. The Young's standard questionnaire was used to collect the data and its reliability and validity were confirmed. We have used SPSS 18.0 software to analyze the data.
Results: The analysis of the results showed that the internet addiction among the students participating in the study was as follows: 6% without internet addiction, 68% mild internet addiction and 31.6% moderate internet addiction.  The internet addiction in the male students has been significantly higher than the female ones. The results analysis has also indicated that there is a significant and direct relationship between the hours of internet use and the extent of the addiction.
Conclusion: Regarding the fact that most of the students in the present study have shown mild internet addiction; then we can hope with a proper planning which will provide the conditions, the students will use the internet more in research and science fields and thus wasting their precious time will be avoided.