Volume 1, Issue 1 (7-2015)
Tabari Biomed Stu Res J 2015, 1(1): 10-18 |
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Ehsan H, Amir Majd Z, Mashayekhi Mazari J, Sharifian Pa Ghalee M, Ayoobi F, Amin F, et al . Comparison of the Effects of Hydro-alcoholic Feru-lago angulata Extract and Phenytoin Cream on Skin Wounds. Tabari Biomed Stu Res J 2015; 1 (1) :10-18
URL: http://tbsrj.mazums.ac.ir/article-1-3443-en.html
URL: http://tbsrj.mazums.ac.ir/article-1-3443-en.html
Homa Ehsan1 
, Zahra Amir Majd2 , Jamileh Mashayekhi Mazari1 , Marziyeh Sharifian Pa Ghalee1 , Fatemeh Ayoobi3 , Fatemeh Amin3 , Sedigheh Sharif Pa Ghalee1 , Elham Hakim Zadeh4 , Mohammad Allah-Tavakoli *5
, Zahra Amir Majd2 , Jamileh Mashayekhi Mazari1 , Marziyeh Sharifian Pa Ghalee1 , Fatemeh Ayoobi3 , Fatemeh Amin3 , Sedigheh Sharif Pa Ghalee1 , Elham Hakim Zadeh4 , Mohammad Allah-Tavakoli *5
1- BSc Department of Physiology, Physiology & Pharma-cology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan Iran
2- Student Gholbaf, kerman, Iran
3- MS Department of Physiology, Physiology & Pharma-cology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan Iran
4- PHD Student Department of Physiology, Physiology & Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan Iran
5- Associate Professor Department of Physiology, Physiology & Pharmacology Research Center
2- Student Gholbaf, kerman, Iran
3- MS Department of Physiology, Physiology & Pharma-cology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan Iran
4- PHD Student Department of Physiology, Physiology & Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan Iran
5- Associate Professor Department of Physiology, Physiology & Pharmacology Research Center
Abstract:
Background & Objectives: Ferulago angulata is one of the most important
herbs used in the traditional medicine for the treatment of skin wounds in
the region of Golbaf located in Kerman, Iran. This study aimed to compare
the effects of ferulago angulata hydro-alcoholic extract and 1% phenytoin
cream on skin ulcers.
Materials & Methods: In this experimental study, 20 male mice were
divided into 4 groups of control, recipi-ents of 1% phenytoin cream and
recipients of hydro-alcoholic extract of ferulago angulata (10 and 100 mg/
ml). The compounds were applied to skin wounds with diameter of 7.85 mm.
Phenytoin cream was applied on the wounds of each subject at doses of 10
and 100 mg/ml for 18 days, and the control group received saline serum.
Level of wound healing was measured at days 3, 6, 9, 12 and 14, and the total
recovery time for each skin wound was calculated as well.
Results: Mean of wound severity was determined at days 12 and 14, and
recipients of the extract in both groups had a significant difference with the
control group (P<0.05). Differences in wound healing in the phenytoin group
and recipients of 10 and 100 mg/kg extract were 1.58 days, 3 days and 4.13
days, respectively. In addition, there was a significant difference in wound
recovery at days 9 and 12 between the phenytoin group and recipients of 100
mg/ml of the extract (P<0.05).
Conclusion: According to the results of this study, hydro-alcoholic extract of
ferulago angulata had a more signifi-cant effect on wound healing compared
to phenytoin cream.
Type of Study: Research (Original) |
Published: 2015/07/15 | ePublished: 2015/07/15
Published: 2015/07/15 | ePublished: 2015/07/15
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