Sharifi A, Naghsh N, Razmi N. Evaluation of the Antioxidant Effects of Green Tea (Camellia sinensis) on Male Albino Mice poisoned with Thioacetamide. Tabari Biomed Stu Res J 2015; 1 (1) :19-27
URL:
http://tbsrj.mazums.ac.ir/article-1-3444-en.html
1- MSc. Student of Biochemistry, Research & Science Branch, Islamic Azad University of Fars, Iran
2- PhD. of Animal Physiology, Associate Professor and Faculty Member of Islamic Azad University, Falavarjan Branch, Isfahan, Iran
3- PhD. of Clinical Biochemistry (Orientation to Cancer), Associate Professor and Faculty Member, Research & Science Branch, Islamic Azad University of Fars, Iran
Abstract:
Background & Objectives: Effects of free radicals and reactive oxygen
species (ROS) on biological systems have been one of the most important
medical concerns. Production of free radicals and ROS is inherent to aerobic
life. This study aimed to investigate the antioxidant effects of green tea
(camellia sinensis) on male Albino mice poisoned with thioacetamide.
Materials and Methods: In this study, thioacetamide was injected
intraperitoneally at doses of 100 and 150 mg/kg. In addition, enzyme
activity of catalase (CAT) and glutathione peroxidase (GPx), as well as the
concentration of malondialdehyde (MDA) as the main source of antioxidants,
were measured in all the study groups.
Results: There was a significant increase in the activities of CAT and GPx,
while a significant decrease was observed in the level of MDA in the mice
receiving combined green tea and thioacetamide compared to the recipients
of thioacetamide alone (P<0.05).
Conclusion: According to the results of this study, the antioxidant properties
of green tea are associated with the presence of a polyphenol called catechin
in this plant.
Type of Study:
Research (Original) |
Published: 2015/07/15 | ePublished: 2015/07/15