Tabari Biomedical Student Research Journal

Background & Objectives: Currently, diabetes is a major problem. Increased
level of blood sugar is one of the effective factors in oxidative stress. Former
studies showed that sports and herbal medicines are the non-pharmaceutical
treatments for diabetes. Accordingly, we aimed to evaluate the effect of aerobic
training and Coriandrum sativum extract on some oxidative stress factors in male
diabetic rats.
Materials & Methods: The present study was conducted on 40 male Wistar
rats randomly divided into control, training, extract-training, and extract groups.
Diabetes was induced through intraperitoneal injection of streptozotocin (55 mg/kg
of body weight). After induction of diabetes, the training group performed aerobic
training for six weeks (50-55% maximum oxygen uptake). The extract group was
orally administered Coriandrum sativum extract (150 mg/kg of body weight daily).
After six weeks, serum levels of total antioxidant capacity (TAC), superoxide
dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) were measured.
Results: The results showed aerobic training and consumption of Coriandrum
sativum extract significantly increased serum levels of TAC, SOD, and CAT and
significantly lowered serum level of MDA (P<0.05).
Conclusion: It can be concluded that aerobic training along with Coriandrum
sativum extract can improve antioxidant defense system and diminish oxidative
factors in diabetic patients.