Volume 4, Issue 2 (6-2022)
Tabari Biomed Stu Res J 2022, 4(2): 23-30 |
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Abdollahi A, Naseh I, Kalroozi F, Kazemi-Galougahi M H, Nezamzadeh M, Frouzanian M, et al . Is there an Association between Side Effects of AstraZeneca, Sputnik, Covaxin and Sinopharm COVID-19 vaccines and Breakthrough Infections?. Tabari Biomed Stu Res J 2022; 4 (2) :23-30
URL: http://tbsrj.mazums.ac.ir/article-1-3771-en.html
URL: http://tbsrj.mazums.ac.ir/article-1-3771-en.html
Amirsaleh Abdollahi1 
, Iman Naseh * 2, Fatemeh Kalroozi3 , Mohammad Hassan Kazemi-Galougahi4 , Maryam Nezamzadeh5 , Mehran Frouzanian1 , Maryam Feyzollahi6 , Mojtaba Yousefi-zoshk7
, Iman Naseh * 2, Fatemeh Kalroozi3 , Mohammad Hassan Kazemi-Galougahi4 , Maryam Nezamzadeh5 , Mehran Frouzanian1 , Maryam Feyzollahi6 , Mojtaba Yousefi-zoshk7
1- School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
2- Department of Infectious Diseases, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
3- Department of Pediatric Nursing, School of Nursing, AJA University of Medical Sciences, Tehran, Iran.
4- Department of Social Medicine, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
5- Department of Critical Nursing, School of Nursing, AJA University of Medical Sciences, Tehran, Iran.
6- School of Nursing, AJA University of Medical Sciences, Tehran, Iran.
7- Department of Pediatrics, School of Medicine, Trauma Research Center, AJA University of Medical Sciences, Tehran, Iran.
2- Department of Infectious Diseases, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
3- Department of Pediatric Nursing, School of Nursing, AJA University of Medical Sciences, Tehran, Iran.
4- Department of Social Medicine, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
5- Department of Critical Nursing, School of Nursing, AJA University of Medical Sciences, Tehran, Iran.
6- School of Nursing, AJA University of Medical Sciences, Tehran, Iran.
7- Department of Pediatrics, School of Medicine, Trauma Research Center, AJA University of Medical Sciences, Tehran, Iran.
Abstract:
Introduction: Safe and efficacious vaccines against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), would contribute to contain the COVID-19 pandemic. In this study, we examined this question that if there is an association between the incidence of side effects and the COVID-19 breakthrough infections.
Material and Methods: This descriptive-analytical cross-sectional study was conducted for two months from June 22 to August 22, 2021. The study method was complete enumeration and 1474 healthcare workers who were medical staff of seven hospitals in Tehran and were vaccinated with one of the AstraZeneca, Covaxin, Sputnik V and Sinopharm vaccines. Two main questions of this questionnaire were the occurrence or non-occurrence of any side effects after receiving the vaccines and the presence or absence of COVID-19 infection after vaccination.
Results: According to the results obtained, in recipients vaccinated with Sinopharm vaccine, the group that reported at least one side effects after receiving the vaccine had a significantly higher COVID-19 infection than the group reported no side effects after vaccination (P<0.001) (RR=4.55). Also in whole sample study Participants who have reported one or more side effect after COVID-19 vaccination, had 3.7 times higher risk of breakthrough infection than others (P<0.001); However Among those vaccinated with AstraZeneca, Covaxin and Sputnik vaccines, no significant difference was observed between the groups with and without side effects after vaccination in terms of later COVID-19 infection.
Conclusion: It seems that participants who have reported one or more side effect after COVID-19 vaccination, had times higher risk of breakthrough infection than others.
Material and Methods: This descriptive-analytical cross-sectional study was conducted for two months from June 22 to August 22, 2021. The study method was complete enumeration and 1474 healthcare workers who were medical staff of seven hospitals in Tehran and were vaccinated with one of the AstraZeneca, Covaxin, Sputnik V and Sinopharm vaccines. Two main questions of this questionnaire were the occurrence or non-occurrence of any side effects after receiving the vaccines and the presence or absence of COVID-19 infection after vaccination.
Results: According to the results obtained, in recipients vaccinated with Sinopharm vaccine, the group that reported at least one side effects after receiving the vaccine had a significantly higher COVID-19 infection than the group reported no side effects after vaccination (P<0.001) (RR=4.55). Also in whole sample study Participants who have reported one or more side effect after COVID-19 vaccination, had 3.7 times higher risk of breakthrough infection than others (P<0.001); However Among those vaccinated with AstraZeneca, Covaxin and Sputnik vaccines, no significant difference was observed between the groups with and without side effects after vaccination in terms of later COVID-19 infection.
Conclusion: It seems that participants who have reported one or more side effect after COVID-19 vaccination, had times higher risk of breakthrough infection than others.
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