Volume 6, Issue 3 (10-2024)
Tabari Biomed Stu Res J 2024, 6(3): 16-26 |
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Khanpour M, Frouzanian M, Baghbanian S M, Ghasemi Hamidabadi H, Khonakdar A, Cheraghmakani H et al . Investigating the Relationship between Vitamin D Status and Multiple Sclerosis; A Case-Control Study. Tabari Biomed Stu Res J 2024; 6 (3) :16-26
URL: http://tbsrj.mazums.ac.ir/article-1-3821-en.html
URL: http://tbsrj.mazums.ac.ir/article-1-3821-en.html
Investigating the Relationship between Vitamin D Status and Multiple Sclerosis; A Case-Control Study
Mohammadreza Khanpour1 
, Mehran Frouzanian * 1, Seyed Mohammad Baghbanian1 , Hatef Ghasemi Hamidabadi1 , Abbas Khonakdar1 , Hamed Cheraghmakani1 , Amirsaleh Abdollahi1
, Mehran Frouzanian * 1, Seyed Mohammad Baghbanian1 , Hatef Ghasemi Hamidabadi1 , Abbas Khonakdar1 , Hamed Cheraghmakani1 , Amirsaleh Abdollahi1
1- Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Abstract:
Introduction: Multiple Sclerosis (MS) affects the central nervous system, causing significant impairments in movement and sensory functions. Genetic and environmental factors, including vitamin D deficiency, play crucial roles in MS susceptibility and severity.
Methods: Ninety-six MS patients were examined, and divided into patient (n=48) and control (n=48) groups matched for age and gender. Various parameters like age, disease onset, vitamin D levels, hair color, sunlight exposure, and sunscreen use were analyzed. Disease severity was assessed using the Expanded Disability Status Scale (EDSS) scores.
Results: Statistical analysis revealed significant differences in age, disease onset, serum vitamin D levels, hair color, and sunscreen use at 40 years old between patient and control groups. However, no significant variances were found in gender, age, eye color, and vitamin D levels based on disease type or EDSS scores. Notably, no substantial correlation was established between vitamin D levels and disability severity in MS patients, potentially due to suboptimal vitamin D supplementation.
Conclusion: Patients with MS exhibited significantly lower levels of vitamin D compared to the control group. No significant correlation was found between vitamin D levels and the severity of disability in MS patients. This lack of correlation could be attributed to the suboptimal administration of vitamin D in MS patients.
Methods: Ninety-six MS patients were examined, and divided into patient (n=48) and control (n=48) groups matched for age and gender. Various parameters like age, disease onset, vitamin D levels, hair color, sunlight exposure, and sunscreen use were analyzed. Disease severity was assessed using the Expanded Disability Status Scale (EDSS) scores.
Results: Statistical analysis revealed significant differences in age, disease onset, serum vitamin D levels, hair color, and sunscreen use at 40 years old between patient and control groups. However, no significant variances were found in gender, age, eye color, and vitamin D levels based on disease type or EDSS scores. Notably, no substantial correlation was established between vitamin D levels and disability severity in MS patients, potentially due to suboptimal vitamin D supplementation.
Conclusion: Patients with MS exhibited significantly lower levels of vitamin D compared to the control group. No significant correlation was found between vitamin D levels and the severity of disability in MS patients. This lack of correlation could be attributed to the suboptimal administration of vitamin D in MS patients.
Type of Study: Research (Original) |
Subject:
Neurology
Published: 2024/10/19 | ePublished: 2024/10/19
Published: 2024/10/19 | ePublished: 2024/10/19
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