Volume 5, Issue 4 (12-2023)
Tabari Biomed Stu Res J 2023, 5(4): 1-10 |
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Nikzad Jamnani A, Alizadeh-Navaei R, Montazeri M, Nikzad Jamnani F, Dadgar K, Sabbaghi Rostami M. Factors Associated with Mortality among Patients with COVID-19 in Intensive Care Units from Referral Heart Center in the North of Iran. Tabari Biomed Stu Res J 2023; 5 (4) :1-10
URL: http://tbsrj.mazums.ac.ir/article-1-3830-en.html
URL: http://tbsrj.mazums.ac.ir/article-1-3830-en.html
Alireza Nikzad Jamnani *1 
, Reza Alizadeh-Navaei2 , Mahbobeh Montazeri3 , Farnaz Nikzad Jamnani4 , Kosar Dadgar5 , Matine Sabbaghi Rostami6
, Reza Alizadeh-Navaei2 , Mahbobeh Montazeri3 , Farnaz Nikzad Jamnani4 , Kosar Dadgar5 , Matine Sabbaghi Rostami6
1- Department of Anesthesiology and Critical Care Medicine, Mazandaran Heart Center & Emam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran
2- Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
3- Toxoplasmosis Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
4- Islamic Azad University, Central Tehran Branch, Faculty of Science, Department of Biology, Tehran, Iran
5- Department of Prosthodontics, Dental Research Center, Mazandaran University of Medical Sciences, Sari, Iran
6- Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
2- Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
3- Toxoplasmosis Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
4- Islamic Azad University, Central Tehran Branch, Faculty of Science, Department of Biology, Tehran, Iran
5- Department of Prosthodontics, Dental Research Center, Mazandaran University of Medical Sciences, Sari, Iran
6- Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Abstract:
Introduction: The clinical spectrum of COVID-19 ranges from asymptomatic cases to severe viral pneumonia, leading to respiratory failure and death, with factors influencing mortality in severe cases being of paramount importance. This study aimed to identify risk factors associated with outcomes in severe COVID-19 patients admitted to the Intensive Care Units (ICU).
Material and Methods: A cross-sectional analysis was conducted on the clinical course of 99 hospitalized patients, aged 25 to 75, with confirmed COVID-19, admitted to the ICU at Fatemeh Zahra Hospital in Sari. Comprehensive medical records and clinical information were collected from admission throughout hospitalization until recovery or death, including the respective dates.
Results: The study revealed that Diabetes Mellitus (DM) and Hypertension (HTN) were significant risk factors in COVID-19 patients. Mortality rates were notably higher in patients who had a history of statin usage and exhibited low saturation in the ICU. Patients administered Chloroquine demonstrated significantly elevated mortality rates, whereas those treated with Oseltamivir in the ICU exhibited significantly lower mortality rates. Mortality was markedly higher in patients receiving interferon and Kaletra in the ICU. Groups with deceased patients experienced significantly higher incidences of cardiac, cardio-renal, and pulmonary complications. Mortality rates were notably higher in patients with abnormal final Electrocardiograms (ECG). Deceased patients also presented with abnormalities in laboratory tests.
Conclusion: The study concludes that Diabetes Mellitus, Hypertension, history of statin usage, specific treatment types, multi-organ complications, and abnormal ECG findings are associated with increased mortality in severe COVID-19 patients.
Material and Methods: A cross-sectional analysis was conducted on the clinical course of 99 hospitalized patients, aged 25 to 75, with confirmed COVID-19, admitted to the ICU at Fatemeh Zahra Hospital in Sari. Comprehensive medical records and clinical information were collected from admission throughout hospitalization until recovery or death, including the respective dates.
Results: The study revealed that Diabetes Mellitus (DM) and Hypertension (HTN) were significant risk factors in COVID-19 patients. Mortality rates were notably higher in patients who had a history of statin usage and exhibited low saturation in the ICU. Patients administered Chloroquine demonstrated significantly elevated mortality rates, whereas those treated with Oseltamivir in the ICU exhibited significantly lower mortality rates. Mortality was markedly higher in patients receiving interferon and Kaletra in the ICU. Groups with deceased patients experienced significantly higher incidences of cardiac, cardio-renal, and pulmonary complications. Mortality rates were notably higher in patients with abnormal final Electrocardiograms (ECG). Deceased patients also presented with abnormalities in laboratory tests.
Conclusion: The study concludes that Diabetes Mellitus, Hypertension, history of statin usage, specific treatment types, multi-organ complications, and abnormal ECG findings are associated with increased mortality in severe COVID-19 patients.
Type of Study: Research (Original) |
Subject:
Infectious Diseases
Published: 2023/12/28 | ePublished: 2023/12/28
Published: 2023/12/28 | ePublished: 2023/12/28
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