Volume 7, Issue 3 (10-2025)
Tabari Biomed Stu Res J 2025, 7(3): 30-35 |
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Frouzanian M, Ashoori A, Baghbanian S M, Ghasemi Hamidabadi H. Investigating the Role of Osteopontin as a Potential Biomarker in Relapsing-Remitting Multiple Sclerosis. Tabari Biomed Stu Res J 2025; 7 (3) :30-35
URL: http://tbsrj.mazums.ac.ir/article-1-3864-en.html
URL: http://tbsrj.mazums.ac.ir/article-1-3864-en.html
Abstract:
Introduction: Multiple sclerosis is a chronic central nervous system disorder with an unknown etiology. Osteopontin is a pro-inflammatory cytokine that has been implicated in MS pathogenesis. This study aimed to investigate OPN levels in relapsing-remitting MS patients and compare them with healthy individuals to determine its potential role as a biomarker.
Methods: A case-control study was conducted on MS patients referred to BooAli Hospital in Sari. Fifty relapsing-remitting MS patients and 30 healthy controls were included. Plasma OPN levels were assessed using ELISA kits, and we considered the p-value < 0.05 significant.
Findings: Among the participants, the MS group was composed of 30 women (60%) and 20 men (40%), while the healthy group comprised 20 women (66.7%) and ten men (33.3%). Notably, OPN levels were significantly elevated in the MS group compared to the healthy individuals (p-value < 0.001). No difference in OPN levels was observed between male and female MS patients (p-value = 0.4). A significant inverse correlation was also identified between the EDSS score and OPN levels (p-value = 0.01).
Conclusion: This study demonstrates elevated OPN levels in relapsing-remitting MS patients compared to healthy individuals, suggesting its potential as a biomarker for disease activity in MS.
Methods: A case-control study was conducted on MS patients referred to BooAli Hospital in Sari. Fifty relapsing-remitting MS patients and 30 healthy controls were included. Plasma OPN levels were assessed using ELISA kits, and we considered the p-value < 0.05 significant.
Findings: Among the participants, the MS group was composed of 30 women (60%) and 20 men (40%), while the healthy group comprised 20 women (66.7%) and ten men (33.3%). Notably, OPN levels were significantly elevated in the MS group compared to the healthy individuals (p-value < 0.001). No difference in OPN levels was observed between male and female MS patients (p-value = 0.4). A significant inverse correlation was also identified between the EDSS score and OPN levels (p-value = 0.01).
Conclusion: This study demonstrates elevated OPN levels in relapsing-remitting MS patients compared to healthy individuals, suggesting its potential as a biomarker for disease activity in MS.
Keywords: Multiple Sclerosis, Osteopontin, Pro-inflammatory cytokines, Case-control study, Relapsing-remitting MS, Biomarker, EDSS score
Type of Study: Research (Original) |
Subject:
Neurology
Published: 2026/01/20 | ePublished: 2026/01/20
Published: 2026/01/20 | ePublished: 2026/01/20
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