Volume 7, Issue 1 (8-2025)
Tabari Biomed Stu Res J 2025, 7(1): 31-44 |
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Ahmadipour F, Lotfi Asrami F, Khonakdar-Tarsi A, Mohammadzadeh N. Investigating the prevalence of liver, heart, and kidney injuries caused by COVID-19 in patients hospitalized at Imam Sari Hospital. Tabari Biomed Stu Res J 2025; 7 (1) :31-44
URL: http://tbsrj.mazums.ac.ir/article-1-3887-en.html
URL: http://tbsrj.mazums.ac.ir/article-1-3887-en.html
1- Department of Biochemistry and Molecular Biology, Shahid University of Medical Sciences, Sari, Iran.
2- Department of Biochemistry, Biophysics, Genetics and Nutrition, School of Medicine Metabolic Disorders Research Center, Golestan University of Medical Sciences
3- Department of Medical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran..
2- Department of Biochemistry, Biophysics, Genetics and Nutrition, School of Medicine Metabolic Disorders Research Center, Golestan University of Medical Sciences
3- Department of Medical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran..
Abstract:
Introduction: COVID-19 has been associated with multiple organ injuries, contributing to increased morbidity and mortality in hospitalized patients. This study aimed to investigate the prevalence of cardiac, renal, and hepatic injuries among deceased and ICU-admitted COVID-19 patients at Imam Sari Hospital.
Methods: A total of 600 patients were included in this cross-sectional study. Demographic data and clinical histories were collected. The presence of organ injuries was determined by a medical team based on laboratory findings and CT scans. Statistical analyses were performed using SPSS version 26, with a significance level set at 0.05. Descriptive statistics and appropriate inferential tests (independent sample t-test, Pearson Chi-square) were used to analyze the data.
Results: The mean age of patients was 51.83 ± 16.70 years, with most patients (42.3%) aged 61–75. Males comprised 53% of the sample. The prevalence of cardiac, renal, and hepatic injuries was 32.0%, 13.7%, and 3.7%, respectively. Older age was significantly associated with all three types of injuries (P < 0.05). No significant association was found between gender and organ injury prevalence. Mortality rates were significantly higher among patients with cardiac (45.8% vs. 5.4%), renal (57.3% vs. 12.2%), and hepatic (36.4% vs. 17.6%) injuries compared to those without these injuries (P < 0.05 for all).
Conclusion: Cardiac, renal, and hepatic injuries are prevalent among severe COVID-19 cases, especially in older patients, and are strongly linked to increased mortality. Gender does not appear to influence the risk of these injuries.
Methods: A total of 600 patients were included in this cross-sectional study. Demographic data and clinical histories were collected. The presence of organ injuries was determined by a medical team based on laboratory findings and CT scans. Statistical analyses were performed using SPSS version 26, with a significance level set at 0.05. Descriptive statistics and appropriate inferential tests (independent sample t-test, Pearson Chi-square) were used to analyze the data.
Results: The mean age of patients was 51.83 ± 16.70 years, with most patients (42.3%) aged 61–75. Males comprised 53% of the sample. The prevalence of cardiac, renal, and hepatic injuries was 32.0%, 13.7%, and 3.7%, respectively. Older age was significantly associated with all three types of injuries (P < 0.05). No significant association was found between gender and organ injury prevalence. Mortality rates were significantly higher among patients with cardiac (45.8% vs. 5.4%), renal (57.3% vs. 12.2%), and hepatic (36.4% vs. 17.6%) injuries compared to those without these injuries (P < 0.05 for all).
Conclusion: Cardiac, renal, and hepatic injuries are prevalent among severe COVID-19 cases, especially in older patients, and are strongly linked to increased mortality. Gender does not appear to influence the risk of these injuries.
Keywords: COVID-19, Cardiac Injury, Renal Injury, Hepatic Injury, Prevalence, Mortality, Multiple Organ Dysfunction
Type of Study: Research (Original) |
Subject:
Biochemistry
Published: 2025/08/19 | ePublished: 2025/08/19
Published: 2025/08/19 | ePublished: 2025/08/19
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