Volume 5, Issue 4 (12-2023)                   Tabari Biomed Stu Res J 2023, 5(4): 55-61 | Back to browse issues page

Ethics code: IR.IAU.PS.REC.1398.670

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Yekani R, Omraninava M, Nasrollahnejad F, Ghasemi Talouki F, Namdar S. Evaluation of the diagnostic value of procalcitonin in acute pyelonephritis indices in patients referred to the hospital. Tabari Biomed Stu Res J 2023; 5 (4) :55-61
URL: http://tbsrj.mazums.ac.ir/article-1-3823-en.html
1- Department of Biochemistry and Biophysics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran,Iran.
2- Assistant Professor, Hospital Administration Research Center ,Sari Branch, Islamic Azad University, Sari, Iran.
3- Department of Medical Sciences, Faculty of Medicine, Sari Branch, Islamic Azad University, Sari, Iran.
4- Assitant Professor, Neurology Department, Faculty of  Medicine, Sari Branch, Islamic Azad University, Sari,Iran.


Introduction: Uncomplicated urinary tract infection (UTI) is a widespread global ailment. The aim of this investigation was to evaluate the diagnostic efficacy of procalcitonin (PCT) in discriminating acute pyelonephritis from other lower urinary tract infections.

Methods: This applied research concentrated on patients with acute pyelonephritis who were referred to Hazrat Valiasr Qaemshahr Hospital. A straightforward (random) sampling technique was implemented. Leukocyte count, ESR, serum CRP, and PCT measurements were obtained from all patients.

Results: Procalcitonin demonstrated positive results in 98.5% of pyelonephritis cases and 5% of cystitis cases, signifying a statistically significant differentiation (P=0.001). The diagnostic accuracy of procalcitonin was 97.7%, while its sensitivity and specificity were 98.5% and 95%, respectively. A notable correlation between serum PCT and CRP levels was observed in patients with acute pyelonephritis (P=0.038). The serum level of PCT in patients with acute pyelonephritis did not manifest any statistically significant variances based on age, gender, or history of urinary tract infection (P > 0.05).

Discussion and Conclusion: Based on the findings of this study and comparisons with existing research, it can be deduced that procalcitonin functions as a dependable indicator for distinguishing acute pyelonephritis from other urinary tract infections. Consequently, its utilization for this purpose is recommended. Ultimately, conducting further studies with a larger sample size and in a multicenter manner is advised to validate the findings obtained in this study.

Type of Study: Research (Original) | Subject: Virology
Published: 2023/12/10 | ePublished: 2023/12/10

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