Volume 7, Issue 1 (8-2025)
Tabari Biomed Stu Res J 2025, 7(1): 11-19 |
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Ethics code: IR.IAU.SARI.REC.1401.067.
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Owrang M, Fazeli Ghadi M, Gholami A. Molecular Diagnosis of class1 integron in Acinetobacter baumanii strains isolated from Patients admitted in hospitals of sari. Tabari Biomed Stu Res J 2025; 7 (1) :11-19
URL: http://tbsrj.mazums.ac.ir/article-1-3882-en.html
URL: http://tbsrj.mazums.ac.ir/article-1-3882-en.html
1- Departent of Medical Laboratory,Faculty of medical sciences,Sar,C.Islamic Azad University, Sari,Iran.
2- Department of Biological Sciences and Technologies,Faculty of Sciences, S
2- Department of Biological Sciences and Technologies,Faculty of Sciences, S
Abstract:
Introduction: Acinetobacter baumannii, is an opportunistic and gram negative, anaerobic and non-fermentative bacteria. It's highly resistance to last line of antibiotics and variable resistance pattern in patients whose infected by this microorganism, makes a potential reason for recognition related genes and it help us to choosing the best strategy for using antibacterial substances in correct way. So, the aim of this study is molecular identification of integron class I in Acinetobacter baumannii strains in hospitalized patients in north of IRAN.
Material and Methods: 28 samples of Acinetobacter baumannii were collected from hospitalized patients in burned and infected units of three hospitals in Sari during the 6 months from February to July of 2019. demographic information was collected from patients and susceptibility pattern of isolates was examined by Kirbey- Bauer method and presence of Integron class I were identified by PCR method.
Results : In this study, the highest resistance and susceptibility to antimicrobial agents in strains with integrons, were related to Amikacin (95.2%) and Cefipim (90.5%), respectively. Frequency of IntI was 75% in all isolated strains. Most samples were related to wound but isolates from sputum were rare.
Conclusion: Upon on results of our study,the high resistance to different classes of antimicrobial agents of isolates have been observed and so high prevalence rate of intI were existing. Statistical analysis showed correlation between integron class I and antimicrobial resistance in all isolates, too.
Material and Methods: 28 samples of Acinetobacter baumannii were collected from hospitalized patients in burned and infected units of three hospitals in Sari during the 6 months from February to July of 2019. demographic information was collected from patients and susceptibility pattern of isolates was examined by Kirbey- Bauer method and presence of Integron class I were identified by PCR method.
Results : In this study, the highest resistance and susceptibility to antimicrobial agents in strains with integrons, were related to Amikacin (95.2%) and Cefipim (90.5%), respectively. Frequency of IntI was 75% in all isolated strains. Most samples were related to wound but isolates from sputum were rare.
Conclusion: Upon on results of our study,the high resistance to different classes of antimicrobial agents of isolates have been observed and so high prevalence rate of intI were existing. Statistical analysis showed correlation between integron class I and antimicrobial resistance in all isolates, too.
Type of Study: Research (Original) |
Subject:
Microbiology
Published: 2025/08/19 | ePublished: 2025/08/19
Published: 2025/08/19 | ePublished: 2025/08/19
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